• the real physical matter of which a person or thing consists;
    • "DNA is the substance of our genes"
  • the choicest or most essential or most vital part of some idea or experience;
  • the idea that is intended;
  • material of a particular kind or constitution;
    • "the immune response recognizes invading substances"
  • considerable capital (wealth or income);
  • what a communication that is about something is about
  • a particular kind or species of matter with uniform properties;
    • "shigella is one of the most toxic substances known to man"

Scrabble Score: 13

substance is a valid Scrabble (US) TWL word

substance is a valid Scrabble Word in Merriam-Webster MW Dictionary

substance is a valid Scrabble Word in International Collins CSW Dictionary

Words With Friends Score: 17

substance is a valid Words With Friends word